SANGRE DE GRADO " DRAGONS BLOOD" 2oz
SANGRE DE GRADO " DRAGONS BLOOD" 2oz
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SANGRE DE GRADO Resin "DRAGONS BLOOD"

Croton lechleri

2 Fluid Ounces (60 ml)


A pure natural
resin extracted from the sangre de grado tree (Croton lechleri) which
is also called "dragon's blood." Sangre de grado resin is a storehouse
of plant chemicals including proanthocyanidins (antioxidants), simple
phenols, diterpenes, phytosterols, and biologically active alkaloids and
lignans. Scientists have attributed many of the biologically active
properties of the resin to two main "active" constituents: an alkaloid
named taspine, and a lignan named dimethylcedrusine.*
For more complete information on this powerful plant of the rainforest,
please see the Plant Database File on Sangre de Grado.

Raintree
Nutrition's sangre de grado resin has been sustainably wild-harvested
in the Peruvian Amazon. It is rich in active and beneficial
phytochemicals which occur naturally in this plant and is unconditionally guaranteed.
Raintree's supply of sangre de grado comes from the high jungle of Peru
where new organic cultivation programs with medicinal plants are
replacing old coca plantations and providing new sources of income for
poor farmers on their existing lands.


Traditional Uses:*
to stop bleeding and to seal, and heal wounds, burns, cuts, tooth
extractions; for herpes virus ulcers (taken internally and applied
topically); for skin fungi, rashes, and dermatitis; for insect bites,
poison ivy and other itchy or allergic skin reactions; for stomach
ulcers, ulcerative colitis, dysentery and diarrhea


Ingredients: 100% pure sangre de grado resin (Croton
lechleri). This plant has been sustainably wild-harvested (without
pesticides or fertilizers) in the Brazilian Amazon and is non-irradiated
and non-fumigated.

Suggested Use: Take 15 drops in water 1-2 times daily. Use topically by applying liberally to affected area of skin. Avoid contact with eyes.

Contraindications: Not to be used during pregnancy or breast-feeding.

Drug Interactions: None known.

Other Observations: Will stain clothing and other textiles.

Third-Party Published Research*


This Raintree product has not been the subject of any clinical research.
All available third-party research on sangre de grado can be found at PubMed.
A partial listing of the published research on sangre de grado is shown below:

Anticancerous & Cytotoxic Actions:

Gonzales, G. F., et al. "Medicinal plants from Peru: a review of plants as potential agents against cancer." Anticancer Agents Med, Chem. 2006 Sep; 6(5) :429-44.

Rossi, D., et al. “Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex.” Phytomedicine. 2003 Mar; 10(2-3): 139-44.

Sandoval, M., et al. “Sangre de grado (Croton palanostigma) induces apoptosis in human gastrointestinal cancer cells.” J. Ethnopharmacol. 2002; 80(2-3): 121–9.

Chen, Z. P., et al. “Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon’s blood.” Planta Med. 1994; 60(6): 541–45.

Pieters, L., et al. “Isolation of a dihydrobenzofuran lignan from South American dragon’s blood (Croton sp.) as an inhibitor of cell proliferation.” J. Nat. Prod. 1993; 56(6): 899–906.

Itokawa, H., et al. “A cytotoxic substance from sangre de grado.” Chem. Pharm. Bull. 1991; 39(4): 1041–42.



Wound Healing, Neuromuscular, & Antioxidant Actions:

Frum, Y., et al. "In vitro 5-lipoxygenase and anti-oxidant
activities of South African medicinal plants commonly used topically for
skin diseases." Skin Pharmacol. Physiol. 2006; 19(6): 329-35.

Rollinger, J. M., "Taspine: bioactivity-guided isolation and
molecular ligand-target insight of a potent acetylcholinesterase
inhibitor from Magnolia x soulangiana." J. Nat. Prod. 2006 Sep; 69(9): 1341-6.

Dong, Y., et al. “Enhancement of wound healing by taspine and its effect on fibroblast.” Zhong. Yao. Cai. 2005; 28(7): 579-82.

Dong, Y. L., et al. “Effect of taspine hydrochloride on skin wound healing in rats and its mechanism.” Zhong. Xi. Yi. Jie. He. Xue. Bao.. 2005 Sep; 3(5): 386-90.

Lopes, M. I., et al. “Mutagenic and antioxidant activities of Croton lechleri sap in biological systems.” J. Ethnopharmacol. 2004 Dec; 95(2-3): 437-45.

Jones, K. “Review of sangre de drago (Croton lechleri)--a
South American tree sap in the treatment of diarrhea, inflammation,
insect bites, viral infections, and wounds: traditional uses to clinical
research.” J. Altern. Complement. Med. 2003 Dec; 9(6): 877-96.

Desmarchelier, C., et al. “Effects of sangre de drago from Croton lechleri Muell.-Arg. on the production of active oxygen radicals.” J. Ethnopharmacol. 1997; 58: 103–8.

Phillipson, J. D. “A matter of some sensitivity.” Phytochemistry. 1995 Apr; 38(6): 1319-43.

Chen, Z. P., et al. “Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon’s blood.” Planta Med. 1994; 60(6): 541–45.

Porras-Reyes, B. H., et al. “Enhancement of wound healing by the alkaloid taspine defining mechanism of action.” Proc. Soc. Exp. Biol. Med. 1993; 203(1): 18–25.

Vaisberg, A. J., et al. “Taspine is the cicatrizant principle in sangre de grado extracted from Croton lechleri.” Planta Med.
1989; 55(2): 140–43.

Macrae, W. D., et al. “Studies on the pharmacological activity of Amazonian Euphorbiaceae.” J. Ethnopharmacol. 1988; 22(2): 143–72.



Pain-relieving & Anti-inflammatory Actions:

Xiangming, L., et al. “Effects of dragon's blood resin and its
component loureirin B on tetrodotoxin-sensitive voltage-gated sodium
currents in rat dorsal root ganglion neurons.” Sci. China C. Life Sci. 2004 Aug; 47(4): 340-8.

Tsacheva, I., et al. “Complement inhibiting properties of dragon's blood from Croton draco. ”Z. Naturforsch. 2004; 59(7-8): 528-32.

Jones, K. “Review of sangre de drago (Croton lechleri)--a
South American tree sap in the treatment of diarrhea, inflammation,
insect bites, viral infections, and wounds: traditional uses to clinical
research.” J. Altern. Complement. Med.
2003 Dec; 9(6): 877-96.

Risco, E., et al. “Immunomodulatory activity and chemical characterisation of sangre de drago (dragon's blood) from Croton lechleri.” Planta Med. 2003; 69(9): 785-94.

Miller, M. J., et al. “Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado.” J. Invest. Dermatol. 2001; 117(3): 725–30.

Perdue, G. P., et al. “South American plants II: Taspine isolation and anti-inflammatory activity.” J. Pharm. Sci. 1979;
68(1): 124–26.



Antimicrobial Actions:

Gurgel, L. A., et al. “In vitro antifungal activity of dragon's blood from Croton urucurana against dermatophytes.” J. Ethnopharmacol. 2005; 97(2): 409-12.

Williams, J. E. “Review of antiviral and immunomodulating properties
of plants of the Peruvian rainforest with a particular emphasis on Una
de Gato and Sangre de Grado.” Altern. Med. Rev. 2001; 6(6): 567–79.

Sidwell R., et al. “Influenza virus-inhibitory effects of
intraperitoneally and aerosol-administered SP-303, a plant flavonoid.” Chemotherapy. 1994; 40(1): 42–50.

Chen, Z. P., et al. “Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon’s blood.” Planta Med. 1994; 60(6): 541–45.

Rao, G. S., et al. “Antimicrobial agents from higher plants. Dragon's blood resin.”J. Nat. Prod. 1982 Sep-Oct; 45(5):
646-8.



Anti-ulcer & Anti-diarrhea Actions:

Tran, C. D., et al. "The role of Amazonian herbal medicine Sangre de Grado in Helicobacter pylori infection and its association with metallothionein expression." Helicobacter. 2006 Apr; 11(2): 134-5.

Paula, A. C., et al. "The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats." Br. J. Nutr. 2006 Aug; 96(2): 310-5.

Fischer, H., et al. “A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells.” J. Ethnopharmacol. 2004; 93(2-3): 351-7.

Jones, K. “Review of sangre de drago (Croton lechleri)--a
South American tree sap in the treatment of diarrhea, inflammation,
insect bites, viral infections, and wounds: traditional uses to clinical
research.” J. Altern. Complement. Med.
2003 Dec; 9(6): 877-96.
Miller, M. J., et al. “Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado.” Am. J. Physiol. Gastrointest. Liver Physiol. 2000; 42: G192–200.

Gabriel, S. E., et al. “A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion.” Am. J. Physiol. 1999 Jan; 276(1 Pt 1): G58-63.